The following is the list of non-league games scheduled for the first week of the 2011 NHIAA football season. The matchups were determined by the final regular-season standings from the 2010 season:

Note: In some cases the home team has yet to be determined.

D1 #1 plays D2 #1: Pinkerton at Bishop Guertin
D1 #2 plays D2 #2: North at Winnacunnet
D1 #3 plays D2 #3: South at Dover
D1 #4 plays D2 #4: Salem vs. Keene
D1 #5 plays D3 #1: Central at Portsmouth (Souhegan and Central already play later in season, so Portsmouth becomes #1)
D1 #6 plays D3 #2: Concord vs. Souhegan
D1 #7 plays D3 #3: Londonderry at Milford
D1 #8 plays D3 #4: Memorial at Hollis/Brookline
D3 #5 plays D2 #5: Bedford at Timberlane
D3 #6 plays D2 #6: Goffstown at Merrimack
D3 #7 plays D2 #7: Pembroke vs. Alvirne
D3 #8 plays D2 #8: Con-Val vs. West
D1 #9 plays D2 #9: Exeter vs. Spaulding